Friday, April 21, 2006

JNCI apr 2006

JNCI Apr 2006

Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor J Natl Cancer Inst 2006; 98: 545-556

Assessing Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial J Natl Cancer Inst 2006; 98: 529-534
Variables that predicted prostate cancer included higher PSA level, positive family history of prostate cancer, and abnormal DRE result, whereas a previous negative prostate biopsy was associated with reduced risk. Neither age at biopsy nor PSA velocity contributed independent prognostic information. Higher PSA level, abnormal DRE result, older age at biopsy, and African American race were predictive for high-grade disease (Gleason score 7) whereas a previous negative prostate biopsy reduced this risk.


Evaluation of Prostate-Specific Antigen Declines for Surrogacy in Patients Treated on SWOG 99-16 J Natl Cancer Inst 2006; 98: 516-521.

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